Active and inactive renin after SQ 14225 (Captopril) administration.
نویسندگان
چکیده
منابع مشابه
Haemodynamics of orally-active converting enzyme inhibitor (SQ 14225) in hypertensive patients.
1. The haemodynamic effects of oral converting enzyme inhibitor (SQ 14225) were assessed in eight patients with severe essential or renovascular hypertension. 2. Mean arterial pressure fell (149 +/- 5 to 127 +/- 8 mmHg, P less than 0.02), because of a fall in total peripheral resistance (6.9 +/- 0.53 to 5.7 +/- 0.40 kPa 1(-1)s m2) without a significant change in cardiac index. Two of the eight ...
متن کاملRelease of active and inactive renin by the porcine kidney.
We studied the relative rates of release of active and inactive renin by the kidney in anesthetized pigs. Renin concentration was determined in arterial and renal venous plasma as follows: (1) before and after stimulation of renin release with isoproterenol or furosemide, (2) after suppression of renin release by extracellular fluid volume expansion, and (3) after administration of propranolol ...
متن کاملAcute reduction in inactive renin after stimulation of active renin by converting enzyme inhibition (CEI) in man
1. Administration of a single dose of captopril, 50 mg, to normal man (n = 7) on a low salt intake induced a 12-5 f 0.9-fold rise in active renin. The rise in active renin was associated with a reciprocal decrease in circulating inactive renin to 1096 or less of control levels. 2. Repeated administration of captopril (50 mg p.0. q 6 h x 3 days) to normal man resulted in increases in both active...
متن کاملEffects of the oral converting enzyme inhibitor, SQ 14225, in a model of low cardiac output in dogs.
Dogs with thoracic caval constriction retain sodium and develop ascites and edema. The role of the renin-angiotensin-aldosterone system in this model of low output failure was evaluated before, during, and after administration of the new orally active converting enzyme inhibitor, 2-D-methyl-3-mercaptopropanoyl-L-proline (SQ 14225). The acute response to the initial oral dose of SQ 14225 (10 mg/...
متن کاملAltered blood pressure and renin responses to converting enzyme inhibition after aprotinin-induced kallikrein-kinin-system blockade.
1. The effect of aprotinin-induced blockade of the kallikrein-kinin system on haemodynamic and biochemical responses to converting enzyme inhibition by SQ 14 225 was evaluated in 26 patients with essential hypertension. 2. SQ 14 225 lowered blood pressure in high, normal and low renin hypertension. In low and normal renin patients, but not in high renin patients, the acute blood pressure-loweri...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1980
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.132.363